Blar i forfatter "Keyse, Stephen M"

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    • Dual-specificity MAP kinase phosphatases in health and disease 

      Seternes, Ole Morten; Kidger, Andrew M; Keyse, Stephen M (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-08)
      It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in mammalian cells and tissues. MKPs provide a mechanism of spatiotemporal feedback control of these key signalling pathways, but can also mediate crosstalk between distinct MAP kinase cascades and facilitate interactions ...

    • Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2 

      Perander, Maria; Al-Mahdi, Rania; Jensen, Thomas Clemens; Nunn, Jennifer Ann Lillebo; Kildalsen, Hanne; Johansen, Bjarne Herold; Gabrielsen, Mads; Keyse, Stephen M; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-02)
      The atypical MAP kinases ERK3 and ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signature sequence S-E-G. However, the regulation of ERK3 and ERK4 phosphorylation and activity is poorly understood. Here we report that the inducible nuclear dual-specificity MAP kinase phosphatase (MKP) DUSP2, a known regulator of the ERK and p38 MAPKs, is unique amongst ...